Localized drug release and effective chemotherapy by hyperthermia-governed bubble-generating hybrid nanocapsule system

Aim: To build up a remote triggering drug delivery system with hyperthermia-responsive ammonium bicarbonate salt and investigate its effects on tumor therapy. Materials & methods: This hybrid nanocapsule system was prepared by a different strategy, doxorubicin (DOX) was encapsulated in the heparin shell first and then ammonium bicarbonate was diffused into the nanocapsules to generate DOX-bicarbonate salt, its characterizations and effects on tumor therapy were investigated. Results: Upon exposure to mild external thermal treatment (42°C), DOX-bicarbonate salt began to decompose with the recovery of DOX fluorescence, carbon dioxide generation and rapid DOX release out of the nanocapsules, exhibiting great abilities to accumulate at tumor site rapidly and inhibit tumor cell growth. Conclusion: These hybrid nanocapsules demonstrate great potential in clinical applications triggering by external thermal treatment.