Using oxidized amylose as carrier of linalool for the development of antibacterial wound dressing

This study aimed to prepare antibacterial wound dressings based on collagen and linalool/oxidized amylose inclusion complex. Encapsulation with oxidized amylose was used as an effective way to introduce linalool into collagen matrix. Our results showed that the content of linalool in the composite dressings was efficiently increased thanks to the solubilization effect of oxidized amyloses. The developed composite dressings possessed porous structure. They had abilities to keep the wound in moist environment and meanwhile prevent the excess exudates accumulation. The incorporation of linalool conferred the composite dressings with excellent antibacterial activities as expected. Moreover, the composite dressing with the highest content of linalool presented enhanced blood compatibility and good cell biocompatibility. This composite dressing effectively promoted granulation tissue formation and accelerated wound healing. It effectively prevented inflammation in regenerated skin tissue and scar formation too. Overall, the developed antibacterial wound dressings hold great potential for use in wound healing applications.