A magnetic restricted access material for rapid solid phase extraction of multiple macrolide antibiotics in honey

A magnetic restricted access material (MRAM) sorbent has been synthesized and for the first time used for the extraction of macrolide antibiotics (MACs). It was prepared using Fe3O4@SiO2 nanoparticles as a support substrate through silanization, atom transfer radical polymerization and hydrolysis reaction. The high magnetic characteristic of the MRAM offers simple isolation from solution and simplified operation procedures as well. The sorbent showed an effective enrichment effect for model MACs (enrichment factor ∼ 520) and also a good exclusion effect towards protein. After treatment with the sorbent, liquid chromatography (LC) coupled with a common ultraviolet absorbance detector offered low limits of detection of 0.076–0.286 μg L−1. The residue of four model MACs in honey samples was determined with recoveries ranging from 92.7% to 109.3%.