A chiral, porous, organic cage-based, enantioselective potentiometric sensor for 2-aminobutanol

A new enantioselective potentiometric sensor containing R-type chiral porous organic cage CC9 as the chiral selector was designed for the assay of 2-aminobutanol. Optimized membrane electrodes displayed a linear dynamic range from 10 −3 ~ 10 −1 mol·L −1 with a detection limit of 2.5 × 10 −4 mol·L −1 and a Nernstian response of 27 ± 0.5mV·decade −1 toward S-2-aminobutanol within the pH range 7.0–10.0. The potentiometric enantioselectivity coefficient ( ) of this sensor was −1.333, indicating that the porous organic cage-based electrode exhibited good discrimination toward S-2-aminobutanol over R-2-aminobutanol.