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One step synthesis of indirubins by reductive coupling of isatins with KBH4

Journal 2017 · IF 2.651 · 发表于 2017 年 3 月 28 日
作者: Cuiling Wang,Jiaxu Yan,Mo Du,Joseph A. Burlison,Chi Li,Yanni Sun,Danqing Zhao,Jianli Liu
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摘要

One step synthesis of the natural product indirubin by reductive coupling of isatin with KBH 4 is described and a possible mechanism for the reaction is proposed. Eleven indirubin derivatives were obtained easily from the corresponding substituted isatin.

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