Ionic liquid-β-cyclodextrin polymer for the separation/analysis of lornoxicam

Ionic liquid-β-cyclodextrin polymer (ILs-β-CDCP) was firstly synthesised and characterised with FTIR, 13C CP/MAS NMR, X-ray powder diffraction, TGA and scanning electron microscope. A novel method of solid phase extraction (SPE) coupled with Ultraviolet–vis spectrophotometry for separation/analysis of lornoxicam was established. ILs-β-CDCP showed a higher adsorption capacity towards lornoxicam than β-CDCP. Adsorption mechanism of ILs-β-CDCP was elucidated by adsorption thermodynamics model, adsorption kinetic model, inclusion constants and FTIR analysis. ILs-β-CDCP exhibited favourable adsorption performance towards lornoxicam from serum and tablet samples. The experimental results herein suggested that ILs-β-CDCP could be successfully applied in the field of pharmic content especially in the treatment of serum.