Highly chemiluminescent metal-organic framework of type MIL-101(Cr) for detection of hydrogen peroxide and pyrophosphate ions

The authors describe a highly chemiluminescent metal-organic framework (MOF) that was obtained by loading the pores of MIL-101(Cr) with luminol. Immobilization is based on Lewis acid-base interactions between the coordinatively unsaturated metal sites of MIL-101(Cr) and the amino groups of luminol. The luminol-loaded MOF displays strong chemiluminescence (CL) in the presence of hydrogen peroxide (H 2 O 2 ) in alkaline solution. Pyrophosphate (PPi), in turn, acts as a quencher of this CL. These findings have been exploited in the design of a CL based method for the determination of either H 2 O 2 or PPi. The assays for H 2 O 2 works in the 3 to 100 μM concentration range and has a detection limit of 0.5 μM. The quenchometric assay for PPi works in the 5 to 70 μM concentration range and has a 1.2 μM detection limit. Luminol-embedded metal-organic frameworks (MOFs) with high chemiluminescent activity were prepared and used for the sensitive determination of either H 2 O 2 or pyrophosphate ions.