pH-sensitive drug controlled release core/shell fibers fabricated by combination of electrospinning and photopolymerization

pH-sensitive drug loaded core shell fibers were fabricated by a combination of electrospinning and UV photo-polymerization. Combretastatin A4 (CA4) was selected as the model drug loaded in PLA to test the pH-sensitivity property of the core shell fibers. The morphology of the fibers was studied by scanning electron microscopy (SEM), and the core shell structure of the fibers was confirmed by transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). The drug release assay was tested via the UV–vis spectrophotometer, and the pH-sensitivity of core shell fibers was tested by drug release assay under pH 5.0 and 7.4.