A selective strategy for determination of ascorbic acid based on molecular imprinted copolymer of o-phenylenediamine and pyrrole

In this work, a novel approach for selective and sensitive detection of ascorbic acid (AA) was proposed combined molecularly imprinted polymers and electrochemical sensor. The molecularly imprinted sensor was prepared by cyclic voltammetry on pencil graphite electrode with pyrrole (Py) and o-phenylenediamine (o-PD) as functional monomers and AA as template molecule. The sensor was evaluated through scanning electron microscope (SEM) and square wave voltammetry (SWV). The factors affecting electrochemical response of sensor were investigated and optimized. Under the optimum conditions, the imprinted sensor exhibited good selectivity and stability. The linear range of the sensor was 1   ×   10 −   6 to 1   ×   10 −   3   mol/L, meanwhile, the detection limit was 2.63   ×   10 −   7   mol/L (S/N   =   3). This molecularly imprinted sensor has been successfully used in AA determination in real tablet samples with good recovery.