Detection of 6-Mercaptopurine by silver nanowires-coated silicon wafer based on surface-enhanced Raman scattering spectroscopy

The silver nanowires (AgNWs) were prepared through the method of polyol. The prepared AgNWs were characterized by TEM image, UV–vis spectroscopy and X-ray diffraction (XRD). AgNWs were assembled onto silicon wafer through entropy-driven self-assembly method. The 521   cm −1 band of silicon was used as internal standard band. The SERS performance of AgNWs-Si substrate was characterized by using R6G as the probe molecule, and the SERS substrate is employed to detect 6-MP. The linear concentration range of 6-MP is 0.05–3.8   μmolL −1 and the corresponding correlation coefficient is 0.994. The method is satisfactory for detecting 6-MP in two kinds of commercial tablets.