Acyl flavone and lignan glucosides from Leontopodium leontopodioides

Two new acyl flavone glucosides, luteolin-4⿲- O -(6- p -hydroxybenzoyl)-β- d -glucopyranoside (leontopodioside A, 1 ) and luteolin-4⿲- O -[6-(2-methylbutyryl)]-β- d -glucopyranoside (leontopodioside B, 2 ), and a new acyl lignan glucoside, lariciresinol-9-angeloyl-4- O -β- d -glucopyranoside (leontopodioside   C, 3 ) were isolated from the whole plants of Leontopodium leontopodioides (Asteraceae). Their structures were determined by spectroscopic and chemical methods. Compounds 1 ⿿ 3 exhibited α-glucosidase inhibitory activity with the half maximal inhibitory concentration (IC 50 ) values of 55.6, 39.7, and 474.9   μM, respectively, in comparison with acarbose (626.3   μM).