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Eco-friendly synthesis of 3-etherified estrones

Journal 2016 · IF 2.645 · 发表于 2016 年 3 月 10 日
作者: Dong-Qing Zheng,Yu Jing,Bing-Ying Zheng,Yun-Fei Ye,Sheng Xu,Wei-Sheng Tian,Hai-Yan Ma,Kai Ding
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摘要

The conventional etherification uses toxic or hardly degradable alkylating agents . An eco-friendly tandem etherification/aromatization is presented to prepare estrone 3-secondary ethers from easily available dienone 1 . Three marketed 3-etherified estrogen drugs were synthesized with the method from commercial available starting material.

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