An Electrochemical Sensing Strategy for Amantadine Detection Based on Competitive Host-guest Interaction of Methylene Blue/β-cyclodextrin/Poly(N-acetylaniline) Modified Electrode

A novel electrochemical strategy for the detection of amantadine (AMD) has been developed based on the competitive host-guest interaction of AMD and methylene blue (MB) with β-cyclodextrin (β-CD). Due to the host-guest interaction, MB molecules can enter into the hydrophobic inner cavity of β-CD, and the MB/β-CD/poly(N-acetylaniline)/glassy carbon electrode displays a remarkable reduction peak due to MB. In the presence of AMD, competitive association to β-CD occurs and the MB molecules are displaced by AMD, resulting in a decrease of reduction peak current of MB. The difference value of the cathodic peak current showed a linear relationship with the AMD concentration.