Xanthones from Garcinia paucinervis with in vitro anti-proliferative activity against HL-60 cells

Three new xanthones, paucinervins H–J ( 1 – 3 ), as well as eleven known compounds ( 4 – 14 ), were isolated from the leaves of Garcinia paucinervis. The structures of the new compounds ( 1 – 3 ) were elucidated by 1D, 2D NMR spectra and HR ESIMS. In vitro antiproliferative activity against human promyelocytic leukemia HL-60 cells was tested, among which, compounds 2 , 5 , 6 and 7 exhibited strong growth inhibitory effects with GI 50 values ranging from 1.30 to 9.08 μM, respectively. Preliminary SARs were also discussed.