Highly water-dispersible silver sulfadiazine decorated with polyvinyl pyrrolidone and its antibacterial activities

Highly water-dispersible silver sulfadiazine (SSD) was prepared by liquid phase method with polyvinyl pyrrolidone (PVP) as a surface modification agent. The structure and morphology of the PVP-modified silver sulfadiazine (P-SSD) were investigated by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and Fourier-transform infrared (FT-IR) spectrometry. The produced particles are ginkgo leaf-like architecture with the sizes of micron-nanometer. Due to hydrophilic PVP decorated on the surface, the P-SSD has excellent dispersion in water over a period of 24   h, which is obviously stable by comparison to that of the commercial silver sulfadiazine (C-SSD). In addition, the P-SSD exhibits good antibacterial activities against Escherichia coli ( E. coli ), Pseudomonas aeruginosa ( P. aeruginosa ) and Staphylococcus aureus ( S. aureus ).