Serum metabolomics in rats models of ketamine abuse by gas chromatography–mass spectrometry

This study aims to evaluate the effect of ketamine on rats by examining the differences in serum metabolites between ketamine abuse group (Ket-group) and control group (Con-group). Compared to the Con-group, the level of phosphate, propanoic acid, ribitol and d -fructose of the Ket-group increased after continuous intraperitoneal administration of ketamine for 7 days, while the level of alanine, glycine, butanoic acid, valine, l -serine, l -proline, mannonic acid, octadecanoic acid and cholesterol decreased. After 14 days’ administration, the level of alanine, butanoic acid, valine, l -leucine, phosphate, l -serine, l -threonine, propanetricarboxylic acid, hexadecanoic acid and oleic acid of the ketamine group increased while the level of mannonic acid, octadecanoic acid and cholesterol decreased. After stopping ketamine administration for 2 days, the level of butanoic acid, phosphate, aminomalonic acid, gluconic acid, hexadecanoic acid, oleic acid and arachidonic acid of Ket-group increased, while the level of glycine, l -lysine and cholesterol decreased. This study can provide invaluable information for the metabolites changes due to ketamine abuse.