DNA-Inspired Electrochemical Recognition of Tryptophan Isomers by Electrodeposited Chitosan and Sulfonated Chitosan

Inspired by the double helix structure of DNA, a simple enantioselective system based on chitosan (CS) was employed for electrochemical enantiorecognition of tryptophan (Trp) isomers. The recognition mechanism was proposed from the supramolecular point of view, which was further verified by the recognition of Trp isomers with sulfonated CS (SCS). The SCS-based chiral system presented the ability of indicating the percentage of d-Trp in racemic mixture, extending future applications of the electrochemical chiral system based on natural polysaccharides.