Simultaneous Electrochemical Determination of Paracetamol and Diclofenac Based on Poly(diallyldimethylammonium chloride) Functionalized Graphene

A simple but sensitive electrochemical method was proposed for simultaneous determination of paracetamol (PCT) and diclofenac (DCF) based on poly(diallyldimethylammonium chloride) (PDDA) functionalized graphene (GR). Although GR enhanced the electro-oxidation peak currents of PCT and DCF, the peak potential difference between two drugs was reduced. By contrast, PDDA-GR greatly increased the electrochemical currents of both analytes while provided well-separated peak potentials. Thus, the voltammetric behavior and simultaneous electrochemical determination of PCT and DCF were investigated on PDDA-GR. The applicability of the proposed method was verified when it was applied in determination of PCT and DCF in pharmaceuticals and lake water.