Novel antitumor dinuclear platinum (II) complexes with a new chiral tetradentate ligand as the carrier group

Seven dinuclear platinum(II) complexes with a novel chiral tetradentate ligand, (1 R ,1′ R ,2 R ,2′ R )- N 1 , N 1′ -(1,4-phenylenebis(methylene))dicyclohexane-1,2-diamine, were designed, synthesized and spectrally characterized. All the complexes were evaluated for their in vitro cytotoxicity against human HepG-2, A549, HCT-116 and MCF-7 cancer cell lines. The results indicated that all compounds showed positive biological activity against HepG-2, A549 and HCT-116 cancer cell lines. In particular, compounds D7 and D2 showed better activity than carboplatin against HepG-2 and A549 and compound D7 also showed an activity close to that of oxaliplatin. Copyright © 2015 John Wiley & Sons, Ltd.