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α-Chymotrypsin-Catalyzed Synthesis of Bis(indolyl)alkanes in Water

Journal 2015 · IF 1.578 · 33(4): 409-412 · 发表于 2015 年 3 月 30 日
作者: Dazhao Sun,Guofang Jiang,Zongbo Xie,Zhanggao Le
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摘要

A novel methodology for the synthesis of bis(indolyl)methanes by the reaction of aromatic aldehydes and indole in water has been developed, and a series of desired products were obtained in moderate to excellent yields (from 65% to 97%) using 1.2 mg/mL α -chymotrypsin as biocatalyst.

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