A Facile and Efficient Approach to Seven-membered Heterocycles by Chlorosilane-catalyzed Domino Reaction

A facile and efficient method has been developed for the preparation of seven-membered heterocycles 1,5-benzoxazepines 3 by MeSiCl 3 /DMF-catalyzed domino reaction via the addition of in situ generated enamines to aldehydes 1 . The advantages of this method are that it operates easily and achieves good yields for a broad scope of aldehyde substrates. And the corresponding products can be readily transformed to other categories of compounds, such as the hydrogenated products 4 , which may have potential application in drug industry.