Graphene Reinforced Hollow Fiber Liquid-Phase Microextraction Combined with HPLC for the Determination of Bisphenol A and 4-Tert-Butylphenol in Bottled Juice

A new analytical method by graphene-reinforced hollow fiber liquid-phase microextraction combined with high-performance liquid chromatography fluorescence detection was developed for the determination of bisphenol A and 4- tert -butylphenol in bottled juices. Several important experimental parameters were studied to get optimal extraction conditions for the analytes. Under the optimized conditions, the method showed a good performance having a linear response in the range from 0.05 to 10.0 ng mL −1 with the correlation coefficients ( r ) of 0.9965–0.9994 and limits of detection of 0.01 ng mL −1 . The relative standard deviations were in the range from 6.4 to 7.2 % at the spiked concentration of 1.0 ng mL −1 . The method combines the high-adsorption capacity of graphene and the excellent clean-up performance of hollow fiber liquid-phase microextraction and has been successfully applied to the analysis of the analytes in bottled juice samples.