Silver chloride loaded mesoporous silica particles and their application in the antibacterial coatings on denture base

Thiol-functionalized MCM-41 type mesoporous silica particles(MSPs) were prepared and loaded with silver chloride to act as antibacterial agents. The antibacterial activity of the silver chloride loaded MSPs(AgCl-MSPs) was evaluated by the minimum bactericidal concentration(MBC) against Candida albicans (ATCC 10231). The AgCl-MSPs with the highest antibacterial activity were then dispersed in hybrid coatings with different mass ratios to fabricate antibacterial coatings. The antibacterial activity of the coatings was tested against Candida albicans (ATCC 10231) and Streptococcus mutans (ATCC 25175). The resulting antibacterial coatings exhibited high antibacterial activity, good adhesion to the substrate and high hardness.