Synthesis of Calcium Phosphate Nanoparticle-Based Docetaxel Delivery System and its In Vitro Anticancer Activity

A new docetaxel (DTX) delivery system has been prepared based on calcium phosphate nanoparticles (CaP NPs) and obtained DTX-adsorbed CaP NPs. The DTX-adsorbed CaP NPs were nearly spherical with mean diameter about 200 nm and a negative zeta potential of −18.8 ± 0.5 mV. They can be well dispersed and stable in water for a long time. In addition, the DTX-adsorbed CaP NPs showed higher cytotoxicity in human nonsmall-cell lung cancer (NSCLC) cell lines than that of DTX at the same experimental conditions. Thus, it could be concluded that CaP NPs can be a promising DTX delivery vehicle in NSCLC chemotherapy.