Kinetic evaluation of the ethanolysis of phosphatidylcholine catalyzed by choline hydroxide

Anhydrous ethanol and choline hydroxide, which are friendlier to human beings, were applied in the process for preparing l -α-glycerophosphocholine. The mechanism of the ethanolysis of phosphatidylcholine catalyzed by choline hydroxide was proposed, the kinetics of the transesterification was evaluated under the catalyst concentration range of 0.006–0.018 mol/L and the temperature range of 293.15–323.15 K. The experimental data were well described by the pseudo-first order equation. The effects of nucleophilic reagent, concentration of catalyst, ethanol-to-oil molar ratios and the temperature were investigated, and the calculated activation energy was 24.28 kJ/mol.