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One-pot preparation of 3-chloropiperidine compounds via Cu(II)-promoted intramolecular chloroamination of unfunctionalized olefins

Journal 2013 · IF 2.803 · 发表于 2013 年 5 月 16 日
作者: Run-Lin Li,Gong-Qing Liu,Wei Li,Yu-Mei Wang,Lin Li,Lili Duan,Yue-Ming Li
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摘要

3-Chloropiperidine compounds were obtained via Cu(II)-promoted one-pot intramolecular chloroamination of N -benzyl-4-penten-1-amines and subsequent rearrangement. The reaction conditions leading to this skeleton were studied, and the structure of the product was confirmed by NMR as well as X-ray diffraction experiments.

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