KOH-catalyzed regioselective ring openings of N-tosylaziridines with malonates in acetone

A simple and efficient method has been developed which describes KOH-oriented catalytic regioselective ring-opening reactions of various N -tosylaziridines with malonates. In the presence of 20   mol% KOH, most N -tosylaziridines can smoothly react with malonates to give the corresponding products in good to excellent yields (up to 99%) and with good to excellent regioselectivity under mild experimental conditions.