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Synthesis of new 3,3′-(1,4-phenylene)bis(1,5-diones) derivatives

Journal 2011 · IF 0.962 · 48(6): 1434-1439 · 发表于 2011 年 8 月 23 日
作者: Qiang Shao,Hui Liu,Ting-Ting Wang,He-Ping Zeng
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摘要

Several 3,3′-(1,4-phenylene)bis(1,5-diones) and their chalcone precursors have been prepared in good to excellent yield via aldol addition and Michael addition starting from 3-acetyl-2,5-dimethylfuran or 3-acetyl-2,5-dimethyl-thiophene with terephthalaldehyde in the presence of appropriate base NaOH or lithium diisopropylamide. The kind and amount of alkali played a critical role in improving the reaction rates and yields of the products. J. Heterocyclic Chem., (2011).

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