An injectable and absorbable magnesium phosphate bone cement designed for osteoporotic fractures

Magnesium phosphate cement as a substitute for osteoporotic fracture implants has gained increasing attention from the public. However, lack of sufficient mechanical strength and osteoinductive capacity, rapid setting time and strongly alkaline environment during degradation have hindered its practical application. Hence, a drug carrier system composed of chitosan and teriparatide solution of liquid phase is constructed and compounded into magnesium phosphate cement (CHI-TR MPC). The CHI-TR MPC composites exhibited almost neutral pH, extended setting time, excellent injectability , enhanced compressive strength , and increased porosity. Meanwhile，the CHI-TR MPC scaffold facilitated the controllable release of ions and drugs, promoted osteogenic differentiation and mineralization through its abundant pore structure , and possessed an appropriate degradation rate . Therefore, this CHI-TR MPC scaffold has huge potential for functional biomaterials design and clinical management in the treatment of osteoporotic fractures.