Fabrication of a MIP-CuMOFs@SA-CS electrochemical sensor based on CuHCF for the highly selective detection of chelerythrine

A novel MOFs hydrogel composite (MIP-CuMOFs@SA-CS) was created by integrating a molecularly imprinted metal–organic framework (MIP-CuMOFs) within a scaffold of sodium alginate-chitosan (SA-CS(Cu 2+ )). The MIP-CuMOFs@SA-CS served as a recognition element to construct an electrochemical sensor for the detection of trace amounts of chelerythrine (CHE). Reduced graphene oxide (rGO) and reduced graphene nanoribbons (rGNRs) were employed for electrode modification and served as the sensing platform. It was to enhance the stability and sensitivity attributes of the sensor system. The signal probe of copper hexacyanoferrate (CuHCF) was generated through the chemical reaction involving Cu 2+ within the composite structure of MIP-CuMOFs@SA-CS with potassium ferricyanide. The experimental results showed that the constructed sensor has a good linear relationship (50 ∼ 500 nmol L −1 ) and a low detection limit (13.83 nmol L −1 ). Moreover, the sensor exhibited good selectivity, recovery rates, and repeatability (RSD = 2.81 %). With the subjected to spiked serum samples, the demonstrating recovery percentages were in the range of 97.17 % to 101.73 %. The CHE molecularly imprinted electrochemical sensor constructed is capable of detecting trace amounts of CHE with the advantages of simplicity, rapidity, high sensitivity, and low cost, which provides a useful reference for the detection of low concentrations of CHE.