Hollow heterostructured CuOx@Co3O4 nanotube arrays for boosting electrochemical glucose detection

Rational design on the microstructure and chemical composition of transition metal-based electrode materials is critical for boosting electrochemical glucose detection. In this work, the hollow heterostructured CuO x @Co 3 O 4 nanotube arrays on Cu foam (CuO x @Co 3 O 4 NTAs/CF) were fabricated. Coupling Co 3 O 4 nanoparticles on CuO x nanotube modulates the electronic structure by heterostructure, enhancing charge transfer during electrocatalytic glucose oxidation. Moreover, the unique hierarchical tubular core-shell structure guarantees abundant well-distributed active sites and rapid pathways for glucose and electrolyte diffusion. Beneficial from the advanced structure, the sensor fabricated with CuO x @Co 3 O 4 NTAs/CF possesses a high sensitivity of 23347.4 μA mM⁻¹ cm⁻² at linear range of 10-527 μM and low limit of detection of 0.56 μM (S/N=3). In addition, the outstanding selectivity, reproducibility and long-term stability (94.5 % for 30 days) as well as good recovery rate in artificial saliva, sweat, and human serum samples are also accessible advantages for our fabricated sensor. The excellent sensing performance of CuO x @Co 3 O 4 NTAs/CF demonstrates its potential application for electrochemical glucose detection.