Multi-active-site antibacterial modification of dopamine-hyaluronic acid hydrogel with N-halamine for skin tissue engineering

Antibacterial hydrogels have attracted much attention in skin tissue engineering due to their superior ability to prevent infection. In this study, we developed an antibacterial hydrogel using a multi-active site N- halamine - modified dopamine-hyaluronic acid hydrogel. The in vitro antibacterial efficacy of the hydrogel exhibited 99.99 % against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus , while also demonstrating excellent biocompatibility. Furthermore, in Escherichia coli- infected skin wounds, the hydrogels effectively suppressed infection and significantly accelerated wound healing. These findings suggest that N -halamine-modified dopamine-hyaluronic acid antibacterial hydrogels have great potential as wound dressings for preventing infection and promoting the healing of infected wounds.