Novel electrochemical sensor strategy: Si-69 modified β-cyclodextrin/nitrogen-doped reduced graphene synthesis and characterization for fipronil detection

Long-term exposure to Fipronil (FIP) roots the vital organ, like liver, kidney, and neurological disorders. Therefore, fast, portable and low-cost sensors are required to detect FIP in environmental and food samples. Here, an electrochemical sensor was successfully developed by using Si-69-β-CD and N-rGO modified a glassy carbon electrode (GCE) for the detection of FIP. The novel Si-69-β-CD composite was prepared by a facile hydrothermal method was subjected to Fourier transform infrared (FT-IR), scanning electron microscopy (SEM), energy dispersive X-ray spectrometers (EDS), powder X-ray diffraction (XRD), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) for morphological and structural confirmation. Results: The electrochemical properties of β-CD were improved by grafting Si-69 as estimated by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The electrochemical studies demonstrated that the developed Si-69-β-CD/N-rGO/GCE sensor exhibited high sensitivity and selectivity for FIP. In addition, under optimized experimental conditions, the Si-69-β-CD/N-rGO/GCE sensor for FIP was shown a wide linear range of 0.01–20 µmol/L and the limit of detection (LOD) of 0.0023 µmol/L. The usefulness of the sensor for the detection of FIP in egg samples was also investigated. Significance: Our study is valueable to the analytical methodology for measurements of Fiproni with a novel method that is robust and sensitive than others. Our current study showed sufficient sensitivity and accuracy and thus is suitable for future application in measuring contaminants in environmental and food samples.