Olfactory-Inspired Separation-Sensing Nanochannel-Based Electronics for Wireless Sweat Monitoring

Human sweat has the potential to be sufficiently utilized for noninvasive monitoring. Given the complexity of sweat secretion, the sensitivity and selectivity of sweat monitoring should be further improved. Here, we developed an olfactory-inspired separation-sensing nanochannel-based electronic for sensitive and selective sweat monitoring, which was simultaneously endowed with interferent separation and target detection performances. The special separation-sensing strategy imparts functional composite membranes with a high sensitivity of 113 mV dec–1 for potassium detection. The excellent mechanical properties and conformability of the Kevlar aramid nanofiber layer bring well-wearing performances to realize continuous wireless sweat monitoring. The recognition between functional molecules and target ions is proved at the molecular level in detail in the article. The replacement of functional molecules proves the universality of the strategy for performance enhancement in intricate biofluid analysis systems.