Perforated MoS2 nanosheets adorned with Ni nanoparticles: An electrochemical sensor for concurrent detection of dopamine and uric acid

Uric acid (UA) and dopamine (DA) are clinical biomolecules associated with various physiological and pathological processes. This study investigates the electrochemical sensing performance of UA and DA based on a dual-modified electrode with holey molybdenum disulfide (h-MoS 2 ) and electrodeposited nickel nanoparticles (NiNPs) GCE/ENi-hMoS 2 . To fabricate an electrochemical sensor, h-MoS 2 nanosheets were synthesized using a simple ultrasonic process from bulk MoS 2 for UA and DA detection. The electrochemical sensing performance of h-MoS 2 and NiNPs modified electrodes were characterized using techniques, such as cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy. Due to the synergetic contribution of h-MoS 2 and NiNPs, the sensor achieved remarkable sensitivity and also exhibited strong anti-inference ability. The sensor exhibited linear ranges between 100–9000 μM and 50–3600 μM, with low detection limits of 7.3 μM and 2.1 μM for UA and DA simultaneously. Additionally, the developed GCE/ENi-hMoS 2 -based electrochemical sensor exhibited high selectivity in the existence of interfering substances, including glucose and ascorbic acid with good stability. This study offers a reference for the fabrication of stable electrochemical sensors consolidated by two-dimensional materials for small-molecule detection.