Persistent luminescent nanoprobes with dual effect radiosensitization for precise radiotherapy

Radiotherapy (RT) is a common modality in the clinical management of breast cancer. However, the radiation damage to healthy tissues caused by the high-dose radiation and the limited therapeutic efficacy with DNA damage repair pose significant challenges in RT. In this work, an intelligent responsive nanoplatform with dual effect radiosensitization (mZGSSM-AMD) has been developed to improve the efficacy of RT. The doping of Lu promotes the generation of reactive oxygen species (ROS) under X-ray irradiation, thereby facilitating DNA breakage. To hinder the repair of damaged DNA, NO is loaded into mZGSSM-AMD, enhancing damage of tumor during radiotherapy. Furthermore, persistent luminescence (PersL) recovers with the degradation of MnO 2 in tumor microenvironment (TME), which guides precision radiosensitization of tumors. Experimental results indicate that growth of tumors is significantly suppressed by effective radiosensitization of mZGSSM-AMD. The mZGSSM-AMD with dual effect radiosensitization exhibits exceptional antitumor effectiveness, providing promising application prospects for the imaging-guided precise radiosensitization therapy.