Tertiary amine-functionalized metal-organic frameworks for high adsorption of perfluoroalkyl and polyfluoroalkyl substances in environmental water samples

Sensitive monitoring of per- and polyfluoroalkyl substances (PFASs) is critical for environmental and health risk assessment. In this work, metal-organic frameworks (MOFs) functionalized with positively charged tertiary amines (UiO-67-CH 2 -N(CH 3 ) 2 ) were synthesized by the one-pot route, which integrated solvothermal MOFs assembly and in-situ reductive amination of formyl groups. The fabricated UiO-67-CH 2 -N(CH 3 ) 2 exhibited exceptional performance as adsorbents for solid-phase extraction (SPE), and the efficient adsorption of PFASs was attribute to the electrostatic attraction and hydrogen bonding. The proposed SPE-HPLC-MS/MS method demonstrated low limit of detection (0.02-0.88 ng·L −1 ), good linearity (0.2-400 ng·L −1 ) and high precision (RSD < 8.18 %). The effectiveness of the established method was assessed through the analysis of PFASs in environmental waters, and recoveries in spiked samples were 84.0-117 % with RSD < 13 %. This study highlighted the efficacy of the functionalized UiO-67-CH 2 -N(CH 3 ) 2 in trace PFASs analysis, advancing their application in environmental monitoring.