Cage-based hyper crosslinked polymers for the effective enrichment of fluoroquinolones from chicken and pork samples

A sensitive method for monitoring fluoroquinolones (FQs) is urgently needed to protect public and environmental health. Herein, a novel porous organic cage-based hyper crosslinked polymer with amino functional groups (named as Cage-HCP1-NH 2 ) was prepared through a facile synthetic method. Due to the unique host-guest interaction, F-π, π-π, F O, and hydrogen bond interactions, the Cage-HCP1-NH 2 exhibited high adsorption performance for FQs with the adsorption capacity up to 408.3 mg g −1 . Then, Cage-HCP1-NH 2 based solid phase extraction was combined with high performance liquid chromatography to sensitively quantify trace amounts of FQs in chicken and pork samples. In the investigated FQs concentration range, the proposed method had excellent linearity (R 2  > 0.9960), high precision (relative standard deviation, RSD < 10 %) and low detection limit (0.30–0.6 ng g −1 ). This study not only presents a viable method for sensitive detection of FQ, but also offers an innovative strategy for the creation of novel cage-based materials and promotes their application in more fields.