Fluorescent Carbon Dot-Functionalized Injectable Self-Healing Hydrogels With Antibacterial Activity for Skin Wound Repair

At present, the development trend of dressing materials is being multifunctional for convenient and long-term nursing care processes of some complicated and infectious wounds. Here, based on the theory of wound moist healing, we offer a series of injectable and self-healing hydrogels with antibacterial activity (CD/C x G y ). Compared with pure hydrogels, the introduction of CDs significantly shortened the gelation time of CD/C x G y from 1036.3 to 301.6 s and lowered the gelation temperature from 40.1°C to 31.9°C. The excellent syringeability and self-healing behaviors endowed the CD/C x G y hydrogels with personalized repair ability. Moreover, the CD/C x G y hydrogels had an 85% antibacterial rate and made the wound basically completely healed on the 14th day, and compared to the initial, the fluorescence intensity also decreased by 44.49%, which had good application potential in visible monitoring of the wound repair process. This study explored the mechanism by which CDs affect the formation of injectable hydrogels. And establishing the application of CD-functionalized injectable hydrogels in wound repair, providing opportunities for wound visualization monitoring and antibacterial treatment. Graphical We have successfully developed a CD-functionalized hydrogel that possesses remarkable antibacterial properties, outstanding optical characteristics, and excellent biocompatibility. Compared to pure hydrogels, the addition of CDs led to a notable reduction in the gelation time and gelation temperature of the CD-functionalized hydrogel. At the same time, the carbon spot functionalized hydrogel also shows excellent antibacterial and visual repair functions, which provid opportunities for wound visualization monitoring and antibacterial treatment.