A bifunctional scaffold achieves a two-stage strategy for repairing tumorous bone defects

Postoperative management of tumorous bone defects remains a formidable clinical challenge due to the persistence of residual malignant cells and substantial bone loss following tumor resection. To overcome this critical issue, an intelligent bifunctional scaffold was engineered through the strategic integration of SrCuSi 4 O 10 nanosheets (SC NSs) into 3D-printed poly (L-lactic acid) (PLLA) scaffold via selective laser sintering technology. This PLLA/SC scaffold achieves a sequential therapeutic mode that coordinates residual tumor eradication with subsequent bone regeneration through stage-specific mechanisms. During the primary therapeutic phase, the integrated SC NSs demonstrate exceptional photothermal conversion efficiency (η = 27.7%), enabling precise hyperthermia-mediated apoptosis of residual tumor cells under near infrared light II region irradiation. Following oncological clearance, the scaffold transitions to osteogenic promotion through sustained ion release kinetics, where strontium and silicate ions synergistically enhance osteoblast differentiation while copper (Cu 2+ ) ions stimulate angiogenic factor secretion. This sequential therapeutic strategy achieved remarkable tumor suppression coupled with substantial bone matrix deposition in Vitro models. This work presents a promising approach for reconstructing tumorous bone defects through multifunctional bio-scaffold engineering.