Effect of Ce4+ on the Osteogenic Activity of Ce-Doped Magnesium Phosphate Composite Materials in Repairing Bone Defects

As the most abundant rare earth element, cerium (Ce) can endow implanted bone repair materials with excellent performance. With magnesium phosphate composite material (MPC) as models, Ce is introduced to improve the osteogenic induction of MPC. A series of Ce-doped MPC (CMPC) with Ce molar ratios of 1, 3, and 5% can be successfully synthesized by the precursor method. The obtained results indicate that CMPC has advantages such as reliable biosafety, excellent osteogenic activity, and excellent mechanical properties. When the content of Ce is 1%, the synergistic effect of Ce 4+ and Mg 2+ released from CMPC-1 is more conducive to promoting cell proliferation and enhancing osteogenic activity, which can accelerate the deposition of calcium junctions and promote the repair of bone defects. These results will provide new routes to improve the bioactivity of CMPC, thereby promoting its clinical application research.