Acetylene black enhances the electrochemical performance of Co@UiO-66-NH2 non-enzymatic glucose sensor

Metal-organic framework materials (MOFs) have shown great promise in electrochemical sensing applications due to their high specific surface area, excellent thermal and chemical stability. However, the practical application of MOFs in non-enzymatic electrochemical glucose sensing is limited by their inherent drawbacks, such as poor electrical conductivity and low mass transfer efficiency. To overcome these challenges, we successfully synthesized a Co@UiO-66-NH 2 /acetylene black (Co@UiO-66-NH 2 /AB) nanocomposite through a dual-solvent method followed by mechanical grinding method and applied it as an efficient electrochemical glucose sensor. Experimental results demonstrate that the Co@UiO-66-NH 2 /AB nanocomposite exhibits significantly enhanced electrochemical sensing performance for glucose detection, compared to pure Co@UiO-66-NH 2 . Specifically, 0.5Co@UiO-66-NH 2 /AB nanocomposite achieves sensitivities of 89.60 μA·mM −1 ·cm −2 and 37.65 μA·mM −1 ·cm −2 in the linear ranges of 0–800 μM and 800–6000 μM, respectively, with a low detection limit of 2.31 μM and a rapid response time of approximately 3.6 s. Additionally, 0.5Co@UiO-66-NH 2 /AB nanocomposite demonstrates remarkable stability, with the current signal remaining nearly constant over an extended period of 3000 s. This enhanced performance can be attributed to the abundant active sites provided by Co@UiO-66-NH 2 , coupled with the enhanced electrical conductivity imparted by acetylene black. Moreover, the sensor exhibits minimal interference from common interfering substances, such as uric acid, dopamine hydrochloride, and ascorbic acid, was observed during glucose detection. Meanwhile, the 0.5Co@UiO-66-NH 2 /AB nanocomposite was also applied for the rapid determination of glucose in bovine serum albumin. Consequently, the Co@UiO-66-NH 2 /AB nanocomposite holds great potential for application in electrochemical biosensors.