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Molecular Imaging of Diabetes-Associated Glutathione S-Transferase Dysregulation Using a Smart Activatable Probe

Journal 2025 · IF 3.9 · 发表于 2025 年 9 月 18 日
作者: Jian He,Dake Wen,Linv Xia,Zhigang Hu,Kai Wang
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摘要

We developed a dual-modal GSTP probe that exhibits GST-responsive fluorescence enhancement and photoacoustic signal reduction. GSTP demonstrated excellent selectivity, sensitivity, and biocompatibility. In diabetic mice, GSTP revealed a decreased level of hepatic GST activity partially restored by metformin treatment, supported by serum analysis and histopathological evaluation, highlighting its clinical translation potential for diabetes monitoring.