Defect-rich graphene stabilized atomically dispersed Cu3 clusters with enhanced oxidase-like activity for antibacterial applications

Nanozyme has attracted great attention due to its diverse enzymatic catalytic activities . But there are still challenges in constructing novel nanozyme with robust catalytic activity. Here, we report an atomically dispersed and fully exposed Cu 3 cluster stabilized on defect-rich nanodiamond-graphene hybrid support (Cu 3 /ND@G) with unique active adsorption sites, which benefit the adsorption and cleavage of O 2 , resulting in enhanced oxidase-like and antibacterial activity . The catalytic rate constant of Cu 3 /ND@G ( K cat = 1.474 × 10 −1 s −1 ) is higher than those of previously reported copper single atom oxidase mimics (0.5 × 10 −3 s −1 ) and even the commercial Pt/C mimics (1.01 × 10 −2 s −1 ). DFT calculation revealed that the atomically dispersed Cu 3 cluster as active center significantly improves the oxidase-like activity, attributing to the easy dissociation of O 2 into reactive oxygen species (•OH). The atomically dispersed Cu 3 cluster with an antibacterial rate of 100% in the NaAc buffer presents its potential application in the field of antibacterial materials.