Photothermal Wood Biopatch Clears Toxins and Exudate to Heal Wounds

Bacteria-infected wound often emerges with accumulation of dense exudates and toxins such as lipopolysaccharide (LPS) and peptidoglycan (PGN) released by bacteria, creating a vicious cycle of nutrient enrichment, bacterial proliferation, and toxin-induced inflammation that aggravates infection. While most current strategies focus primarily on antibacterial activity, they often neglect the critical roles of exudate clearance and inflammation control. Here, a wood-based biopatch (pro-bioP) is designed to accelerate bacteria-infected wound healing through a photothermal-triggered programmed therapeutic strategy. This approach integrates photothermal bacteria-killing, photothermal enhanced exudate drainage, and capture of LPS or PGN to mitigate excessive inflammation. Both in vitro and in vivo results demonstrate that pro-bioP exhibits potent antibacterial efficacy, efficient removal of viscous exudates, and strong anti-inflammatory activity, thereby promoting rapid tissue repair. As mentioned above, the pro-bioP provides a strategy for wound therapy with bacterial infection and accompanying inflammation.