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AIE fluorophore with enhanced cellular uptake for tracking esterase-activated release of taurine and ROS scavenging

Journal 2016 · IF 3.544 · 196: 335-350 · 发表于 2016 年 6 月 14 日
作者: Jun Wang,Yinglong Wu,Fang Zeng,Shuailing Huang,Shuizhu Wu
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摘要

Fluorophores with aggregation-induced emission (AIE) characteristics are attractive and versatile tools for both chemical sensing and biological imaging. Herein, we designed and synthesized a fluorescent light-up system CTPE-Tau with enhanced cellular uptake ability. The system possesses several advantages, such as a large Stokes shift, low cytotoxicity, and good photostability. Also, it has been successfully utilized to track esterase-activated release of taurine and to scavenge intracellular ROS, and shows great potential for trackable visualized therapy.

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