Constructing and characterization of cyclodextrin metal organic framework and soybean hull polysaccharide polymer composite carriers: Enhancing curcumin delivery

This study aims to create composite carriers by combining cyclodextrin metal organic frameworks (CD-MOFs) with soybean hull polysaccharide (SHP) polymers for enhanced performance. A cubic structured composite carrier was successfully synthesized, exhibiting potential for delivering functional factors. Interaction between cyclodextrin (CD) and SHP was predominantly driven by hydrogen bonding forces, as evidenced by Fourier transform infrared spectroscope (FTIR), Raman spectroscopy. Characterization methods such as Powder X-ray diffraction (XRD), Differential scanning calorimetry (DSC), and FTIR confirmed successful encapsulation of Curcumin (Cur) within γ-CD-MOF@SHP. At 35 °C, with a Cur to carrier mass ratio of 1:3, loading efficiency improved after 24 h of immersion. SHP demonstrated a protective effect on Cur, reducing release in the stomach while maximizing release in the intestine, thus enhancing Cur utilization. Additionally, γ-CD-MOF composites were shown to stabilize functional factors and regulate their release. Overall, the combination of MOFs and polymers holds promise for functional factor delivery.