Antibacterial bone cement prepared by isobornyl acrylate monomer shows decent mechanical strength and antibacterial activity

A new type of antibacterial bone cement that relies on surface stereochemistry and is added with antibacterial monomer isobornyl acrylate (BA) is reported. In this study, BA was integrated into poly(methyl methacrylate) (PMMA) bone cement through liquid-phase modification to create a non-leaching antibacterial bone cement (NLBC). The maximum temperature, setting time, antibacterial activity, mechanical strength, and biocompatibility of this NLBC were comprehensively evaluated. The results showed that the BA cement exhibited exceptional antibacterial and mechanical properties. The 30wt% BA cement demonstrated an antibacterial activity of 81.0 ± 3.1% against Staphylococcus aureus and a compressive strength of 72.10 ± 1.97 MPa. The BA cement exhibited good biocompatibility both in vitro and in vivo. Furthermore, we compared the antibacterial activity, mechanical properties, and biocompatibility of the BA cement with three previously reported bone cements, which contain the antibacterial monomers 2-(tert-butylamino)ethyl methacrylate (TBAEMA), methacrylate derived from benzothiazole (BTTMA), nitrofuran methacrylate (NFMA), respectively. The findings of this study have important implications for the advancement of antibacterial bone cement and its application in medical implants.