Corona-shaped DNA hybrid nanoplatform for multi-stimulate cancer therapy

The fabrication of DNA-based nanomaterials with specific functionalities is crucial for advancing tumor therapy. Herein, a novel and facile approach was presented to construct a corona-shaped DNA hybrid nanoplatform, which involved the anchoring of rolling circle amplification (RCA) products on near-infrared (NIR) light-responsive gold nanoflowers (AuNFs). The incorporation of AS1411 aptamer into the RCA product endowed the nanoplatform with the capability of multivalent targeted binding to cancer cells. The nanoplatform exhibited good biocompatibility, notable NIR absorption and robust photothermal conversion, thereby enabling controlled drug release in response to dual NIR/pH stimulation. The developed nanoplatform holds great promise for targeted and responsive cancer treatments.