Molecule Engineering of Coumarin to Reverse Aggregation-Caused Quenching: Facile Access to BioAIEgens

Aggregation-induced emission luminogens (AIEgens) have been extensively investigated and widely used in biomedical fields. However, AIEgens are mostly derived from petrochemicals, leading to challenges of renewability, sustainability and biocompatibility. Therefore, it’s of striking prospect to construct bioproduct-based AIEgens (BioAIEgens) based on the natural profits. Herein, we proposed a straight forward method named “Rotor-Alicyclic” strategy to prepare BioAIEgens with high fluorescence and produce reactive oxygen species (ROS) activities as well as high biosafety. We prepared four BioAIEgens by introducing two rotors and a naturally rigid alicyclic moiety into coumarin molecule. The AIE performances were evaluated, especially the fluorescence and production of ROS activities. Mechanistic study proved the two rotors introduction can destroy the planar structure, and the rigid alicyclic moiety can limit the molecular motion. Furthermore, the biosafety was carefully investigated in vitro and in vivo , demonstrating the high biocompatibility. Summarily, we developed a facial engineering method to prepare BioAIEgens.